For an oocyte for being Completely ready for fertilization and progress into an embryo, the best set of genes must be turned on. Namekawa suspected this pre-programming of your oocyte genome comes about in several levels — the very first 1 starting up throughout the time a feminine is born. He thought that chromatin remodeling proteins did A lot of the function, by shifting spools around.
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Namekawa thinks that in human oocytes, adjustments in these styles could disrupt the delicate choreography of genes remaining turned on and off at the correct periods — leaving them unprepared for fertilization or growth into nutritious embryos. Variations in chromatin construction being an oocyte ages might also impression the way that chromosomes segregate through mobile division.
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